Adenosine 3′,5′-Monophosphate Increases Capacity for RNA Synthesis in Rat Liver Nuclei
- 18 June 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3989) , 1237-1238
- https://doi.org/10.1126/science.172.3989.1237
Abstract
Liver nuclei isolated from rats injected with adenosine 3′,5′-monophosphate exhibit an increased capacity for RNA synthesis compared with nuclei from control animals. This effect, which is highly specific for the cyclic nucleotide. can be observed within 1 hour after injection in both unoperated and adrenalectomized rats. These findings suggest that induction of enzyme synthesis mediated by way of adenosine 3′,5′-monophosphate may be controlled, at least in part, at the level of gene transcription.Keywords
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