Factors influencing the release of renin in patients under chronic dialysis treatment.

Abstract
Plasma renin activities [PRA] (resting PRA, post-dialysis PRA and .DELTA.PRA) were studied in 61 patients under chronic dialysis treatment. Removed Na and removed-water were estimated at each dialysis. .DELTA.PRA/removed-Na and .DELTA.PRA/removed-water were calculated as indices in response to the removal of Na and water during the dialysis. Resting PRA (pre-dialysis PRA) was positively correlated to .DELTA.PRA/removed-Na, .DELTA.PRA/removed-water, serum osmolality and diastolic blood pressure, but negatively to serum Na concentration, age and pulse pressure/diastolic blood pressure. Statistically significant factors controlling the resting PRA were .DELTA.PRA/removed-Na. .DELTA.PRA/removed-water, and serum Na concentration. Resting PRA was slightly correlated to diastolic blood pressure and age. Post-dialysis PRA was significantly correlated to the resting PRA, .DELTA.PRA/removed-Na, .DELTA.PRA/removed-water, serum Na concentration and age, but not to the blood pressure indices.

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