Deletion Polymorphism ofDisc1Is Common to All 129 Mouse Substrains: Implications for Gene-Targeting Studies of Brain Function
- 1 August 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 173 (4) , 2407-2410
- https://doi.org/10.1534/genetics.106.060749
Abstract
We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.Keywords
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