HMG‐X, a Xenopus gene encoding an HMG1 homolog, is abundantly expressed in the developing nervous system
- 26 September 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 352 (2) , 191-196
- https://doi.org/10.1016/0014-5793(94)00909-0
Abstract
We used a PCR-based subtraction cloning procedure with Concanavalin A-treated and untreated animal caps from stage 9 Xenopus embryos to search for genes the expression of which is induced during neurogenesis. One of these genes was found to encode a homolog of mammalian HMG 1 and 2, hence named HMG-X. HMG-X mRNA was maternally transmitted, up-regulated in neuroectoderm-derived tissues throughout early development, and eventually down-regulated in all adult tissues examined except ovary. Our data suggest that we have identified a gene for a member of the HMG1/2 family that could have an important role in neurogenesis.Keywords
This publication has 35 references indexed in Scilit:
- Harnessing the writhe: a role for DNA chaperonesin nucleoprotein- complex formationTrends in Biochemical Sciences, 1994
- Roads to neuralness: Embryonic neural induction as derepression of a default stateCell, 1994
- Neural Induction by the Secreted Polypeptide NogginScience, 1993
- The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.Genes & Development, 1993
- High mobility group proteins 1 and 2 function as general class II transcription factorsBiochemistry, 1990
- The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in XenopusDevelopmental Biology, 1989
- Determinants of messenger RNA stabilityCell, 1987
- Effect of Concanavalin A and vegetalizing factor on the outer and inner ectoderm layers of early gastrulae of Xenopus laevis after treatment with Cytochalasin BCell Differentiation, 1985
- A major developmental transition in early xenopus embryos: II. control of the onset of transcriptionCell, 1982
- HMG-proteins 1 and 2 are required for transcription of chromatin by endogenous RNA polymeraseBiochemical and Biophysical Research Communications, 1982