Further support for the postsynaptic action of substance P and its blockade with baclofen in neurons of the guinea-pig hypothalamus in vitro
- 1 July 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (7) , 759-761
- https://doi.org/10.1007/bf01967965
Abstract
Summary Effects of substance P on neurons of the guinea-pig hypothalamus in vitro and antagonism between substance P and baclofen were investigated. Substance P increased the firing rate of neurons in the medium containing 0 mM Ca2+ and 12 mM Mg2+. The excitatory action of stubstance P was antagonized by a low dose of baclofen whereas that of acetylcholine was not antagonized even by much higher doses of baclofen.Keywords
This publication has 11 references indexed in Scilit:
- Specific binding of 3H-substance P to rat brain membranesNature, 1980
- Electrophysiology of mammalian hypothalamic and interpeduncular neurons in vitroCellular and Molecular Life Sciences, 1979
- Substance P causes direct depolarisation of neurones of guinea pig interpeduncular nucleus in vitroNature, 1979
- Substance P and noncholinergic excitatory synaptic transmission in guinea pig sympathetic ganglia.Proceedings of the Japan Academy, Series B, 1979
- Actions of the p-chlorophenyl derivative of GABA, lioresal, on nociceptive and non-nociceptive units in the spinal cord of the catBrain Research, 1976
- Post morten changes and regional distribution of substance P in the rat and mouse nervous systemBrain Research, 1976
- Is Lioresal (Baclofen) an antagonist of substance P?Brain Research, 1976
- Is β-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?Cellular and Molecular Life Sciences, 1976
- Antagonism between Lioresal and substance P in rat spinal cordBrain Research, 1975
- Excitatory action of hypothalamic substance P on spinal motoneurones of newborn ratsNature, 1974