Reaction of Aziridines with Dianions Derived from β-Ketoesters: Application to the Preparation of Substituted Pyrrolidines

1 January 1993

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1993 (10) , 764-766
https://doi.org/10.1055/s-1993-22601

Abstract

The nucleophilic ring opening of N-tosyl aziridines using the dianions derived from ß-ketoesters has been studied. Acid-mediated cyclisation of the resulting amino ß-ketoesters to a number of substituted pyrrolidines has also been examined.

Keywords

DIANIONS
SS KETOESTERS
Β KETOESTERS
ACID MEDIATED
NUCLEOPHILIC RING
AMINO SS
AZIRIDINES USING
RESULTING AMINO

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