Correlation between segmental mobility and the location of antigenic determinants in proteins
- 1 September 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 311 (5982) , 123-126
- https://doi.org/10.1038/311123a0
Abstract
Most continuous antigenic determinants of tobacco mosaic virus protein (TMVP), myoglobin and lysozyme correspond to those surface regions in the protein structure, as determined by X-ray crystallography, which possess a run of high-temperature factors along the polypeptide backbone, that is, a high segmental mobility. The mobility of an antigenic determinant may make it easier to adjust to a pre-existing antibody site not fashioned to fit the exact geometry of a protein. The correlation found between temperature factors and antigenicity is better than that between hydrophilicity and antigenicity.Keywords
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