A CASE REPORT OF PITUITARY TUMOR PRESENTING AS FORBES-ALBRIGHT SYNDROME: DETERMINATION OF PITUITARY PROLACTIN CONTENT

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Abstract
The patient is a 29 year old Japanese female, married at 21. Her menstrual periods started at 13, but stopped at 17. She complained of severe headache and right side hemianopsia in 1959 (age 22), and was diagnosed as pituitary tumor, which was removed subcapsularly at the Tokyo University Hospital. The tumor had polygonal chromophobe cells. After the 1st operation, her menstruation reappeared several times until her 1st pregnancy (age 23). Her puerperium was normal but lactation had failed to stop, and persisted with amenorrhea for about 5 years up to the present. Physical examination and laboratory data showed slight obesity with hirustism and oily skin. The urinary excretion of GTH [gonadotrophic hormone] was less than normal. The urinary excretion of 17-KS [Keto steroid] and 17-OHCS [hydroxycorticosteroid] and estrogens was a little more than the patients with usual chromophobe adenoma. The thyroid and adrenal function remained within normal limits. The pituitary adenoma grew again in 1965, and right side hemianopsia appeared with severe headache. Reoperation was performed, and the tumor showed the same histological characteristics as in the 1st operation. Patients with these syndrome might have overproduction of prolactin in the pituitary. The prolactin content of this tumor tissue was measured by the pigeon crop sac test, and showed a remarkably higher value than that of the control pituitary tissues obtained from another patient with usual chromophobe adenoma.

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