Biomedical Application of an Isotope Selective Nondispersive Infrared Spectrometer for 13CO2 and 12CO2 Concentration Measurements in Breath Samples

1 July 1994

journal article
analytics
Published by Taylor & Francis in Isotopenpraxis Isotopes in Environmental and Health Studies

Vol. 30 (2) , 253-257
https://doi.org/10.1080/00211919408046741

Abstract

A newly developed isotope selective nondispersive infrared (NDIR) spectrometer for the measurement of ¹³CO₂ and ¹²CO₂ concentrations in breath samples was applied as a low cost and very simple to operate alternative to isotope ratio mass spectrometry (IRMS). We used this device for several biomedical applications ([¹³C]urea breath test, [¹³C]leucine metabolism, [¹³C]methacetin catabolism of rats) and found that the results agree very well with IRMS.

Keywords

This publication has 4 references indexed in Scilit:

A Sensitive Isotope Selective Nondispersive Infrared Spectrometer for ¹³CO₂ and ¹²CO₂ Concentration Measurements in Breath Samples
Isotopenpraxis Isotopes in Environmental and Health Studies, 1994
Leucine Oxidationin vivo: Inter-and Intraindividual Variation in Healthy Subjects as Assessed by Oral L-[1-13C]Leucine Loads
Isotopenpraxis Isotopes in Environmental and Health Studies, 1994
Measurement of carbon-13 dioxide/carbon-12 dioxide abundance by nondispersive infrared heterodyne ratiometry as an alternative to gas isotope ratio mass spectrometry
Analytical Chemistry, 1986
Determination of Isotope Ratios, e.g., in Tracer Work, by an Infrared Absorption Method
The Journal of Chemical Physics, 1951