EFFECTS OF INTRAVITREOUS INJECTION OF DRUGS ON THE CHOLINESTERASE OF THE RETINA
- 1 December 1965
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 43 (6) , 737-742
- https://doi.org/10.1038/icb.1965.58
Abstract
Summary: The cholinesterase activity of excised retinas was measured after intravitreous, intramuscular, and intracarotid injection of various combinations of diisopropylfluorophosphate, octamethylpyrophosphoramide, 1,3 bis (4‐hydroxyi‐minoethylpyridinium) propane dibromide (C434) and acetylcholine.Cholinesterase activity of the retina could be manipulated independently in each eye, without systemic effects, by intravitreous injection of drugs even if these drugs would not have penetrated from the blood to the retina. The advantages of using retina for biochemical and pharmacological studies on neural tissues are discussed.Keywords
Funding Information
- U.S. Public Health Service (NB 04427)
This publication has 2 references indexed in Scilit:
- MAXIMAL INHIBITION OF CHOLINESTERASE IN THE CENTRAL NERVOUS SYSTEMBritish Journal of Pharmacology and Chemotherapy, 1960
- OXIMES OF αω‐DIQUATERNARY ALKANE SALTS AS ANTIDOTES TO ORGANOPHOSPHATE ANTICHOLINESTERASESBritish Journal of Pharmacology and Chemotherapy, 1959