Vaccination of adults with live attenuated mumps virus vaccine

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Abstract
A controlled study with live attenuated mumps virus vaccine, B level Jeryl Lynn strain, was conducted on adults without a history of mumps. Altogether, 95 men and women were vaccinated and sera were obtained prior to and 28 days following vaccination for the purpose of measuring initial serologic status for mumps and for ascertaining antibody responses. Only 20 (21%) of the adults who were vaccinated were initially without antibody to mumps. In 19 of these seronegative persons antibody developed following vaccination, giving a neutralizing antibody seroconversion rate of 95%. None of the persons given the vaccine had fever or other untoward clinical reaction referable to the vaccine. It was concluded that the vaccine is safe and efficacious.

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