Sequential chemotherapy for adenocarcinoma of unknown primary

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Abstract
Twenty-five adult patients with adenocarcinoma of unknown primary origin were treated with oral tegafur followed by the combination of cyclophosphamide, adriamycin and cis-diamminedichloroplatinum(II) (CAP) if they failed to respond to tegafur. One complete and 3 partial responses were obtained in 17 patients evaluated for response to tegafur; 2 partial responses were achieved in 9 patients who received the CAP regimen after failing to respond to tegafur. The overall response rate with the treatment program in 21 evaluable patients was 29%; the overall median survival was 18 wk. The administration of these regimens did not significantly improve the survival duration.

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