A DOSE-RESPONSE-LIKE RELATIONSHIP BETWEEN MINUTE VENTILATION AND EXERCISE-INDUCED BRONCHOCONSTRICTION IN YOUNG ASTHMATIC-PATIENTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 61  (6) , 342-346
Abstract
Adolescent patients (7) with bronchial asthma performed bicycle exercise tests on several occasions, within 1 wk. After the determination of baseline pulmonary function (using spirometry, maximal expiratory flow-volume curves and body plethysmography), all subjects were exercised on the bicycle ergometer for 10 min. On each occasion a different level of minute ventilation (.ovrhdot.VE, l/min) was achieved, because of different work performed. Following each exercise test, the degree of exercise-induced bronchoconstriction was assessed. The degree of bronchoconstriction, as measured by pulmonary function tests, is a function of .ovrhdot.VE measured during exercise. A dose-response-like relationship, i.e., level of .ovrhdot.VE vs. bronchoconstrictive response, seems to be an important individual characteristic of the airway reactivity of young patients with bronchial asthma.

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