The Antiallergic Agent Amoxanox Suppresses SRS-A Generation by Inhibiting Lipoxygenase
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 79 (3) , 231-237
- https://doi.org/10.1159/000233978
Abstract
Amoxanox has potent antiallergic activity because it inhibits the release of chemical mediators such as histamine and leukotrienes. We studied the in vitro effect of amoxanox on arachidonic acid metabolism, including the lipoxygenase and cyclooxygenase pathways. Amoxanox inhibited calcium ionophore A23187-induced formation of 5-HETE, LTB4, SRS-A (LTC4, LTD4 and LTE4), and 12-HETE in rat peritoneal resident monocytes. These results indicate that amoxanox inhibits 5- and 12-lipoxygenases. The compound, however, did not affect the formation of TXB2 or 6-keto-PGF1α in guinea pig lung fragments and PGE2 or PGF2α in bovine seminal vesicles, suggesting that it did not inhibit cyclooxygenase. These results show that the antiallergic action of amoxanox is associated, at least in part, with the reduction of leukotrienes due to the inhibition of lipoxygenases.Keywords
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