Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor
- 1 September 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 262 (2) , 659-663
- https://doi.org/10.1042/bj2620659
Abstract
Three major autophosphorylation sites are located near the C-terminus of the epidermal growth factor receptor, but a fourth site is repeatedly detected. We report here the purification and sequencing of a tryptic peptide containing this site, Tyr-1086. Furthermore, we demonstrate that additional phosphopeptides are observed following both partial digestion and overdigestion. Finally, we show that Tyr-1086 can be phoshorylated in intact cells.This publication has 36 references indexed in Scilit:
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