Abstract
For inactive mice, metabolism below the critical temperature was proportional to the thermal gradient, and body temperature and insulation were constant in animals acclimated to 6 °C., but not in those acclimated to 20 °C. For active mice, the same work caused the same increase in metabolism at all temperatures, but metabolism during work was not proportional to the thermal gradient. During work, with decreasing temperature, body temperature was relatively stable in 6 °C. mice but fell appreciably in 20 °C. mice. Over-all insulation was lower in working than in inactive animals, but in the 6 °C. acclimated mice there was a substantial improvement in insulation during work as the temperature decreased. Reports on other animals and humans also suggest that work may lower insulation. When work decreases insulation, much of the heat produced by the work, unlike that produced by SDA, may not be available for maintaining body temperature in a cold environment.

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