Diffusion-Weighted Imaging of Acute Corticospinal Tract Injury Preceding Wallerian Degeneration in the Maturing Human Brain

  • 19 June 2003
    • journal article
    • Vol. 24  (6) , 1057-1066
Abstract
BACKGROUND AND PURPOSE: Wallerian degeneration, the secondary degeneration of axons from cortical and subcortical injury, is associated with poor neurologic outcome. Since diffusion-weighted (DW) imaging is sensitive to early changes of cytotoxic edema, DW imaging may depict the acute injury to descending white matter tracts that precedes Wallerian degeneration; this injury is not visible on conventional CT or MR images in the maturing human brain.

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