Long-Continued Function of Normal Blood-Forming Tissue Transplanted Into Genetically Anemic Hosts2

Publisher Website
Google Scholar
Abstract
Evidence has been presented for the very long persistence and genotypically autonomous functioning of isologous normal ww blood-forming tissue in X-irradiated genetically anemic WWυ hosts. For more than 500 days the blood pictures of anemic mice implanted with isologous ww fetal liver cells corresponded closely with those of untreated control ww mice of comparable age and genetic background rather than with those of untreated WWυ mice. Even after this period, mean cell volumes and erythrocyte counts indicated that implanted ww cells were functioning. Importance of the W-genotype of implanted cells was demonstrated by the lack of a beneficial result from injections of isologous WW or WWυ fetal cells in irradiated anemic hosts. The ww-implanted WWυ anemics tended to live longer than both irradiated and nonirradiated control WWυ anemics; this suggested that the genotype of functioning hematopoietic tissue may have an important influence upon longevity.