Human Alpha1-Microglobulin in Various Hepatic Disorders

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Abstract
Human α1-microglobulin (α1m) levels were studied in the sera and urine of patients with various liver diseases. In patients with acute hepatitis and chronic hepatitis it was almost within the normal range. A significant decrease of serum α1-m, however, was demonstrated in patients with compensated liver cirrhosis (p < 0.05) as well as in those with decompensated liver cirrhosis (p < 0.001). The most striking decrease was noted in patients with fulminant hepatitis (p < 0.001). Its concentration in hepatoma was generally within the normal range, but there was 1 hepatoma case with the high concentration of α1-m. Serum α1-m levels correlated significantly with serum albumin, plasma fibrinogen and cholinesterase activity. As compared with the level in normal individuals, the patients with decompensated liver cirrhosis had significantly low urinary α1-m (p < 0.005), reflecting the findings for sera. These results indicated that the liver plays an important role in α1m synthesis, and its quantitation may be used for evaluating severe liver damage.

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