BETA-ADRENERGIC-BLOCKADE, REGIONAL LEFT-VENTRICULAR BLOOD-FLOW AND ST-SEGMENT ELEVATION IN CANINE EXPERIMENTAL MYOCARDIAL ISCHEMIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 205  (3) , 646-656
Abstract
The effects of dl-propranolol, d-propranolol, dl-pindolol and dl-practolol on regional myocardial blood flow (assessed by means of tracer microspheres) and on .**GRAPHIC**. elevation in ischemic and nonischemic areas of the canine left ventricle were investigated. dl-Propranolol and dl-pindolol, but not dl-practolol and d-propranolol, induced blood flow redistribution from the epicardium to the endocardium both in ischemic and nonischemic areas. dl-Propranolol-induced redistribution was abolished by atrial pacing at the control heart rate value. Apparently, the redistribution phenomenon only occurs if both a bradycardia-inducing .beta.1 adrenoceptor blockade and a coronary vessels .beta.2 adrenoceptor blockade are simultaneously achieved. All 4 drugs significantly decreased .**GRAPHIC**. elevation in eschemic areas. Under atrial pacing, this effect was abolished with dl-practolol but only reduced with dl- and d-propranolol, suggesting that, besides bradycardia, membrane stabilization might be involved in protection against .**GRAPHIC**. elevation in ischemic areas.

This publication has 1 reference indexed in Scilit: