Complement receptor mediates enhanced flavivirus replication in macrophages.
Open Access
- 1 July 1983
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 158 (1) , 258-263
- https://doi.org/10.1084/jem.158.1.258
Abstract
Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.Keywords
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