SKIN GRAFT ENHANCEMENT STUDIES WITH ANTIGENIC DIFFERENCES ARISING FROM THE H-2K, H-2D, AND H-2L LOCI

Publisher Website
Google Scholar
Abstract
Enhancement of skin grafts is possible when there are antigenic differences arising from the K end but not the D end of the H-2 complex. Anti-Ia [immune response-associated antigen] antibodies in the anti-K end sera are responsible for graft prolongation. The anti-H-2K antibodies are not responsible for graft prolongation; D end antisera are not enhancing as they lack Ia antibody activity. These findings were extended by 2 separate approaches. By using appropriate congenic and recombinant strains, enhancement for D end antigenic differences could be observed, provided that Ia antibodies were also present. In this way, H-2D and H-2K alloantigens are similar and both require additional I region differences to enable skin graft enhancement to be observed. H-2Kb, H-2Dd and H-2Ld mutants were examined and putative antisera used to attempt to prolong graft survival in these unique coisogenic strains. In no case was graft survival significantly prolonged, even in the presence of demonstrable antibodies. In 2 different approaches, wherein single gene products were examined (derived by mutation and by recombination), enhancement of skin allografts could not be observed, unless additional Ia alloantigenic differences were also present.

This publication has 0 references indexed in Scilit: