Hemoglobin Mizuho or Beta 68 (E 12) Leucine → Proline, a new Ufistarle Variaiit Associated with Severe Hemolytic Anemia
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 1 (5) , 467-477
- https://doi.org/10.3109/03630267709027864
Abstract
A hitherto undescribed, unstable hemoglobin was discovered in a four-year-old Japanese girl with relatively severe hemolytic anemia requiring monthly blood transfusion Although no abnormal hemoglobin was detectable by electrophoresis at pll 8.6 and 7.0, heat denaturation and isopropanol tests gave positive results. Chemical analyses of the heat labile henioglohin have demonstrated an amino acid substitution of a prolyl for the leucyl residue at the 68th (E 12) position. Remarkable clinical improvement was observed after splenectomy.This publication has 10 references indexed in Scilit:
- Abnormal human haemoglobins: I. The comparison of normal human and sickle-cell haemoglobins by “fingerprinting”Published by Elsevier ,2003
- Hemoglobin Hirosaki (α 43 [CE 1] Phe→Leu), a new unstable variantBiochimica et Biophysica Acta (BBA) - Protein Structure, 1975
- Haemoglobin Saki α2β214 Leu → Pro (A11) structure and functionBiochimica et Biophysica Acta (BBA) - Protein Structure, 1975
- Haemoglobin Perth: β32 (B14) Leu→Pro, An Unstable Haemoglobin Causing HaemolysisBritish Journal of Haematology, 1973
- Thin-layer chromatography of sub-nanomole amounts of phenylthiohydantoin (PTH) amino acids on polyamide sheetsAnalytical Biochemistry, 1973
- Hb-Genova (α2β228(bio)leu→pro); methods for detection and analysis of unstable hemoglobinsClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- A Simple Method for the Detection of Unstable HaemoglobinsBritish Journal of Haematology, 1972
- [26a] Sequence analysis with dansyl chloridePublished by Elsevier ,1972
- Hereditary non-spherocytic haemolytic anaemia with post-splenectomy inclusion bodies and pigmenturia caused by an unstable haemoglobin Santa Ana-beta-88 (F4) leucine--proline.Journal of Medical Genetics, 1968
- Human fibrinopeptides isolation, characterization and structureBiochimica et Biophysica Acta (BBA) - General Subjects, 1966