ACTIVITY OF 1-P-(3,3-DIMETHYL-1-TRIAZENO) BENZOIC-ACID POTASSIUM-SALT IN M-5076/73A OVARIAN RETICULAR CELL-SARCOMA OF THE MOUSE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (11) , 1945-1948
Abstract
1-p-(3,3-Dimethyl-1-triazeno) benzoic acid potassium salt (DM-COOK) was tested on M 5076/73A (M5) mouse sarcoma at a dose of 40 or 50 mg/kg per day (days 6-14) after i.m. transplant of 7 .times. 105 cells, with or without surgical removal of the primary tumor on Day 14. Treatment at either dose level resulted in reduction of the primary tumor weight to .apprx. 50% of that in the controls; striking antimetastatic effects were observed. When a dose of 40 or 50 mg/kg of DM-COOK was followed by surgery, there were 14% and 40% long-term survivors, respectively, but the higher dose caused .apprx. 30% toxic deaths. After i.v. injection of 103 or 105 M5 tumor cells, no artificial metastases appeared in DM-COOK-treated mice; all control animals had metastatic involvement in the liver, spleen, ovaries and kidneys.