DIAGNOSIS OF ANEMIAS IN INFANCY AND CHILDHOOD

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Abstract
The diagnostic features of the anemias in infancy and childhood are influenced by numerous physiologic and anatomic changes which take place within and outside of the hematopoietic system. Alterations of the blood need to be interpreted, therefore, against the shifting background of normal hematologic changes which take place from birth through childhood. During this period the condition of the peripheral blood may reflect the results of the isoimmunization of the mother by fetal blood factors, abnormalities in maternal hematopoiesis, prematurity, the effect of rapid body growth, limitation of reserve bone marrow, reactivation of fetal blood sites and the greater inherent capacity of the hematopoietic system of younger subjects to react excessively to stimuli which would have little effect on an adult. In this age period the anemias develop insidiously, and diagnosis before specific criteria are established may be difficult. Diagnosis is facilitated by the appraisal of data derived from various

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