Tuberculosis Research

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Abstract
Tuberculosis (TB) is a killer with impressive credentials. Over the past 2 centuries, it has killed a billion people.1Currently it is the leading cause of mortality from a single infectious agent—accounting for 26% of preventable adult deaths in the developing world.2In the coming decade, it is slated to kill at least 30 million people.3 See also p 1502. The synergy between the epidemics of TB and human immunodeficiency virus (HIV) constitutes a global public health crisis of staggering dimensions. In persons infected with HIV, infection withMycobacterium tuberculosisis much more likely to progress rapidly to active disease, which is increasingly difficult to diagnose and more complicated to treat.4Globally, TB is now the leading cause of death among persons with acquired immunodeficiency syndrome (AIDS), killing 1 of every 3 people who die with AIDS.3To date, the dual scourge of TB and