Photoreceptoral basis for altered dark-adaptation in retinal degeneration (RCS) rats

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Abstract
The fast PIII rod mediated photoreceptor response to flashes of monochromatic light was investigated in isolated retinae of the RCS rat at age 30 days. (The RCS strain of rats suffers from an inherited retinal degeneration transmitted as a recessive gene.) A loss of both sensitivity and maximum response amplitude was found, with a concurrent slowing of the response kinetics. A rod abnormality may underlie the altered adaptational properties in these retinae.