Assay of Digitalis Concentrations in Blood

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Abstract
Research in the metabolism of the cardiac glycosides has been hampered by the lack of methods sufficiently sensitive to measure the minute concentrations of digitalis in the blood of patients receiving therapeutic doses. Investigations using 14C and 3H-labeled cardiac glycosides have yielded basic information as well as data of distinct clinical importance.1 Elegant, sensitive methods such as that described by Smith and his associates in this issue of the Journal should now make it possible to measure the concentrations of cardiac glycosides in blood without administering radioisotopic digitalis preparations. Determinations are possible within one or several hours. These methods represent . . .