Personal learning plans are being introduced and developed across the breadth of medical education - from the early years of undergraduate training through to continuing professional development for experienced clinicians. This Guide shows how and where they can be used, charting their history across higher education in the UK, indicating how they link with other professional development initiatives such as appraisal and revalidation, and giving an educational rationale for their use in enhancing lifelong learning. It offers a simple, stage-by-stage strategy for developing a personal learning plan, and for supporting others as they undertake the process themselves.