Adrenal Cortical Function in Experimental Alcoholism in Dogs.

Publisher Website
Google Scholar
Abstract
Summary The effect of acute ethanol administration on corticosteroid secretion has been studied in dogs by the direct measurement of 17-hydroxycorticosteroid concentration in peripheral plasma, Procedures associated with the basic experimental design such as repeated handling of the animals, intravenous infusion of a sizeable volume of fluid and serial blood sampling over a 6 1/2-hour span of time had no appreciable effect on steroid plasma levels. Intravenous infusion of ethanol in different doses resulted in a significant elevation of plasma 17-hydroxycorticosteroid concentration but because of a high degree of variability in the results, no definite dose-response relationship could be established. Ethanol intoxication did not alter the normal disposal rate of exogenous hydrocortisone after the intravenous administration of this steroid. These observations suggest that the ethanol-induced corticosteroid response in the dog may be mediated by ACTH secretion.

This publication has 1 reference indexed in Scilit: