Blood Serotonin Levels in the Attention-Deficit Disorder

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Abstract
To the Editor: Abnormalities in the monoamine systems of patients with behavior disorders (e.g., autism, schizophrenia) continue to be investigated for a potential etiologic role. Evidence has been advanced that children with hyperactivity (now referred to as the attention-deficit disorder) have low levels of blood serotonin,1 high levels of blood serotonin (in borderline cases),2 and the same level of blood serotonin as controls.3 One study4 also reported that the administration of pyridoxine increased levels of whole-blood serotonin in six hyperactive children who had low serotonin levels. This change in serotonin level was accompanied by the suppression of hyperactivity symptoms. The . . .

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