Polyamines in Type 5 Adenovirus-Infected Cells and Virions

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Abstract
The incorporation of l-[14C]ornithine and [14C]putrescine into putrescine, spermidine, and spermine in type 5 adenovirus-infected KB cells was identical to that in uninfected control cells early in infection, but incorporation into putrescine stopped after 8 to 12 h and the rate of incorporation into spermidine was reduced between 12 and 20 h after infection. The amount of polyamines found associated with purified virus could neutralize a maximum of 3 to 4% of the virus DNA, but the small quantities of polyamines detected could not be distinguished from nonspecific binding of polyamines to virions. These data suggest that polyamines are probably not integral components of adenovirus particles.