Inhibition of B‐Cell Function by Concanavalin‐A‐Induced Suppressor Cells

Publisher Website
Google Scholar
Abstract
The in vitro immune response of normal spleen cells to the thymus‐independent antigen dinitrophenylated levan (DNP‐LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti‐sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con‐A‐induced suppressor cell activity.