Aminoacids as Chiral Synthons1: Preparation of Enantiomerically Pure (R) and (S) Malic Acids and its Application to the Synthesis of 3-Hydroxy 4-Butanolide
- 1 February 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (2) , 183-190
- https://doi.org/10.1080/00397918608057706
Abstract
Malic acid has been proved to be an extremely valuable chiral synthon for enantiospecific synthesis of complex molecules such as monensin2, amphotericin B3, variou s hydroxytetrahydrofurans4, lactones5,6 and pheromones7. However the (S) isomer only is easily available8; the (R) isomer is more difficult to obtain and is generally prepared by a synthetic way9.Keywords
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