Conray: A New Cardiovascular and Urographie Contrast Medium

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Abstract
Clinical trial of a new low-viscosity contrast agent, Conray (iothalamic acid), was made in a series of over 300 patients. The observations indicate that the intravenous injection of the 60% solution for urography is practically devoid of unpleasant reactions; injection of this same solution into the peripheral arterial system (carotid-vertebral and femoral) is also well tolerated. The 80% compound produces the usual moderate to severe wave of heat and flushing common to all of the recently introduced concentrated organic iodide compounds although severe side-effects are rare. It is concluded that while Conray, 80%, appears to be a highly satisfactory cardiovascular contrast agent, search for the ideal compound which would be entirely non-toxic, with higher radio-opacity, and injectable in smaller quantities, must continue.

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