Platelet-Aggregation Response to Single or Paired Aggregating Stimuli after Low-Dose Aspirin

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Abstract
To the Editor: Aspirin inhibits platelet function by irreversible acetylation of platelet cyclooxygenase.1 , 2 In healthy subjects,3 , 4 patients who have had a myocardial infarction,5 or patients with atherosclerosis6 or cerebrovascular disease,7 repeated doses of 20 to 40 mg of aspirin have been found to inhibit platelet aggregation induced by a single stimulus, with concomitant sparing of cyclooxygenase activity outside the platelets.3 , 8 Using pairs of aggregating agents, investigators have observed full aggregation in subjects who had ingested one high dose of aspirin (500 to 650 mg)9 10 11 or in platelets exposed to aspirin in vitro.12 , 13 We evaluated the effect of repeated low-dose aspirin . . .