OBSTRUCTION OF AQUEOUS OUTFLOW BY LENS PARTICLES AND BY HEAVY-MOLECULAR-WEIGHT SOLUBLE LENS PROTEINS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 17  (3) , 272-277
Abstract
Enucleated human eyes were perfused via the anterior chamber at 25 mm Hg pressure with lens particles (whole lens homogenates) in 1 series of experiments and with soluble lens proteins from human cataractous lenses in another series. Adding 1% of a homogenate of a single cataractous lens to the anterior chamber induced a 68% decrease in outflow. Perfusion with H[heavy]MW soluble lens proteins (1 mg/ml; MW more than 150 million) caused a 60% decrease in outflow in 1 h. In neither series was the obstruction to outflow relieved by subsequent irrigation of the anterior chamber with balanced salt solution or .alpha.-chymotrypsin. Apparently lens particles and soluble lens proteins can directly obstruct the aqueous outflow pathways of human eyes. Such obstruction may be a significant factor in certain lens-induced glaucomas.

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