Potent Inhibitors of the Hedgehog Signaling Pathway
- 15 February 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 51 (5) , 1108-1110
- https://doi.org/10.1021/jm070694n
Abstract
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.Keywords
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