Biosynthesis of coclaurine

Abstract
Feeding of tyrosine, tyramine, dopa, dopamine, and 4-hydroxyphenylpyruvic acid has been examined in the biosynthesis of coclaurine in Annona reticulata. While tyramine, dopa, and dopamine contribute to the formation of the phenethylamine portion of coclaurine, tyrosine and 4-hydroxyphenylpyruvic acid are incorporated into both halves. Tracer experiments show that coclaurine is biosynthesised via the intermediacy of norcoclaurine-1-carboxylic acid, 1,2-didehydronorcoclaurine, and norcoclaurine.

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