The Synthesis of 1′-Methyl Carbocyclic Thymidine and its Effect on Nucleic Acid Duplex Stability
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (10) , 853-855
- https://doi.org/10.1055/s-1994-23030
Abstract
The enantioselective synthesis of the title compound 1 has been accomplished in 18 chemical steps starting from cyclopentadiene via epoxide 2 and amine 9 as the central key intermediates. Oligodeoxyribonucleotides incorporating several modified building blocks 1 are still capable of hybridizing to complementary RNA, albeit with lower affinity than their natural counterparts.Keywords
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