Human Autologous Rosettes. II. Prognostic Significance of Variations in Autologous Rosette-Forming Cells in the Peripheral Blood of Cancer Patients2

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Abstract
The distribution of autologous rosette-forming cells (A-RFC) was determined in 55 samples of peripheral blood mononuclear cells from healthy adult donors and 407 samples from 112 cancer patients. The mean percentage and absolute number of A-RFC were significantly reduced in the cancer patients compared to the healthy adult donors. These values for A-RFC were even more significantly reduced in patients with cancer relapse than in patients with complete remission of cancer. Thus diminution of this pertinent subset of T[thymus-derived]-lymphocytes has interesting clinical value by its being closely related to an adverse prognosis.