Particle Size Distribution of Rat Lung Residues After Exposure to Fiberglass Dust Clouds

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Abstract
One group of rats exposed for 2 months to airborne fiberglass dust less than 3.9 microns in aerodynamic equivalent diameter received intratracheal papain prior to inhalation in order to produce emphysema, while a second group did not. The animals were periodically sacrificed after exposure, a few serial sections of the lungs of each animal were taken, and lung tissue digestion was performed to obtain lung dust residues for analysis. Samples of each lung residue were counted and sized by optical phase contrast microscopy and by electron microscopy.

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