Experimental Approach to the Pathogenesis of Retrolental Fibroplasia

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Abstract
There is convincing evidence that exposure to oxygen is intimately related to the occurrence of retrolental fibroplasia in premature infants.* The more immediate relationship is, however, not exactly known, and many problems remain to be solved. The importance of a lowering of the environmental oxygen concentration for the development of vasoproliferating changes is an unsettled question. The study by Bedrossian and associates2 pointed to a higher incidence of the disease in infants suddenly withdrawn from high oxygen concentrations as compared with the occurrence in children slowly weaned. On the other hand, it was pointed out in the preliminary report of the cooperative study3 that the prolongation of the stay of the infant in oxygen to permit slow weaning might increase the risk of developing the disease. Another problem concerns the question as to whether external factors other than oxygen exposure influence the pathological vascularization of the retina. In

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