Flash-Vacuum Pyrolysis of 1,2,4-Triazolides: A New Synthesis of Functionalized Oxazoles

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Abstract
Tandem mass spectrometry (MS/MS) has been applied to investigate the behaviour of 1,2,4-triazolides upon flash-vacuum pyrolysis (FVP) conditions. Monosubstituted (position 5) oxazoles (loss of nitrogen) and in some cases oxygenated cumulenes (loss of 1,2,4-triazole) are the most important pyrolysis products. Pyrolysis at a preparative scale indicates moreover the interest of the technique as the synthetized oxazoles were usually unknown or very difficult to prepare owing the conventional procedures.
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