HYPERPRODUCTION AND GENE AMPLIFICATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN SQUAMOUS-CELL CARCINOMAS

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 76  (8) , 663-666
Abstract
Human squamous cell carcinoma tissue was screened to determine the epidermal growth factor (EGF) receptor level. In 9 out of 15 cases, increased EGF binding was observed relative to normal adjacent tissue. In 2 tissue samples (SCE1 and SCL1) amplification of the EGF receptor gene and increased mRNA level were also observed. In 2 other cases (SCE2 and SCL3), EGF receptor gene amplification did not occur. There, apparently, is an alternative mechanism for EGF receptor hyperproduction, independent of gene content, active in these tissues. A possible role of EGF receptor hyperproduction is envisioned in human neoplasia.

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