Inhibition and Modulation of γ-Secretase for Alzheimer's Disease
- 1 July 2008
- journal article
- review article
- Published by Elsevier in Neurotherapeutics
- Vol. 5 (3) , 391-398
- https://doi.org/10.1016/j.nurt.2008.05.010
Abstract
No abstract availableKeywords
This publication has 73 references indexed in Scilit:
- Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein miceBMC Neuroscience, 2007
- Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]The Journal of Pharmacology and Experimental Therapeutics, 2005
- Purification and Characterization of the Human γ-Secretase ComplexBiochemistry, 2004
- Discovery of a Subnanomolar Helical d-Tridecapeptide Inhibitor of γ-SecretaseJournal of Medicinal Chemistry, 2004
- Detergent-Dependent Dissociation of Active γ-Secretase Reveals an Interaction between Pen-2 and PS1-NTF and Offers a Model for Subunit Organization within the ComplexBiochemistry, 2003
- Designed Helical Peptides Inhibit an Intramembrane ProteaseJournal of the American Chemical Society, 2003
- Differential Effects of Inhibitors on the γ-Secretase ComplexJournal of Biological Chemistry, 2003
- Reconstitution of γ-secretase activityNature Cell Biology, 2003
- NOTCH ANDPRESENILIN: Regulated Intramembrane Proteolysis Links Development and DegenerationAnnual Review of Neuroscience, 2003
- Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesodermNature, 1997