Decreased Perfusion in Young Alcohol-Dependent Women as Compared With Age-Matched Controls
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis in The American Journal of Drug and Alcohol Abuse
- Vol. 33 (1) , 13-19
- https://doi.org/10.1080/00952990601082605
Abstract
Aim: To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women. Methods: Eight alcohol dependent women and 8 controls (all ages 18–25) received single-slice resting perfusion-weighted MRI (directly proportional to brain blood flow), with slices located above the corpus callosum. Results: Alcohol-dependent women had decreased perfusion in prefrontal and left parietal regions. Conclusions: Reduced perfusion has not previously been reported in young, physically healthy alcohol dependent females, yet is consistent with previously reported decreased cerebral activity in alcohol dependence.Keywords
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