Absent or Delayed Preovulatory Luteinizing Hormone Surge in Experimental Diabetes Mellitus

Publisher Website
Google Scholar
Abstract
The proestrus preovulatory luteinizing hormone (LH) surge was absent or delayed in more than 56% of untreated streptozotocin-diabetic rats. Absence of LH surge was associated with anovulation. Insulin treatment for 10–14 days restored the diminished surge and ovulation frequency. Pituitary LH release in response to exogenous gonadotropin-releasing hormone administration in diabetic rats was not different from controls. Impaired hypothalamic function may comprise the basis for the increased incidence of infertility in diabetes mellitus.

This publication has 0 references indexed in Scilit: