A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique
- 1 October 1983
- journal article
- research article
- Published by Springer Nature in Neuroradiology
- Vol. 25 (5) , 315-318
- https://doi.org/10.1007/bf00439210
Abstract
Quantitative studies of the influence of anticonvulsant drugs on bone mineral content of 88 epileptics were performed by a microcomputer-aided densitometer system. The results showed that the mineral content decreases significantly with the duration of the therapy. This decrease was found to be approximately 1.2% per year for a Diphenylhydantoin (DPH) monotherapy and 1.8% per year and 2.0% per year for a DPH plus Phenobarbital and DPH plus Carbamazepin combination therapy.Keywords
This publication has 8 references indexed in Scilit:
- Die Bestimmung des Knochenmineralgehaltes mit Hilfe einer mikroprozessorgestützten DensitometeranlageBiomedizinische Technik/Biomedical Engineering, 1980
- Interaktionen bei antiepileptischer KombinationstherapieDeutsche Medizinische Wochenschrift (1946), 1979
- Interaction of Diphenylhydantoin (Phenytoin) and Phenobarbital with Hormonal Mediation of Fetal Rat Bone Resorption In VitroJournal of Clinical Investigation, 1978
- Evidence of Osteomalacia in an Outpatient Group of Adult EpilepticsEpilepsia, 1977
- Incidence of Anticonvulsant Osteomalacia and Effect of Vitamin D: Controlled Therapeutic TrialBMJ, 1973
- Radiologic Bone Changes and Hypocalcemia with Anticonvulsant Therapy in EpilepsyAnnals of Internal Medicine, 1972
- Phenobarbital-Induced Alterations in Vitamin D MetabolismJournal of Clinical Investigation, 1972
- Osteomalacia with Long-term Anticonvulsant Therapy in EpilepsyBMJ, 1970