Purpura and Septicemia Due toNeisseria subflava

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Abstract
PETECHIAE of the skin, associated with fever, headache and neck stiffness, were recognized as a reliable sign of meningitis before Weichselbaum described the meningococcus in 1887. The presence of the meningococcus in the bloodstream was first reported in 1899 by Gwyn1 during his residency training period under Osler. Subsequently, meningococci were demonstrated to be present in the petechial skin lesions.2 The concept of meningococcemia separate from meningitis was clearly defined by Herrick3 in 1919, but most patients with meningococcal petechiae then proceeded to meningitis, and only after antimicrobial agents came into use were appreciable cases of meningococcemia without meningitis reported. . . .

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